Generally, Paget’s disease of bone (PDB) is a common condition characterized by focal areas of increased and disorganised bone remodelling.
Furthermore, It mostly affects the axial skeleton, and bones that are commonly involve include the pelvis, femur, tibia, lumbar spine, skull and scapula.
It is seldom diagnose before the age of 40, but gradually increases in incidence.
The disease is common in Caucasians from northwest and southern Europe but is rare in Scandinavians, Asians, Chinese and Japanese.
These ethnic differences persist after migration, supporting the importance of genetic factors in the aetiology, but the incidence of PDB has fall in some countries over the past 25 years, suggesting that environmental triggers also play a role.
The body of a person with Paget’s disease might generate new bone in incorrect locations or remove old bone from its intended areas.
This process can lead to weakness in the bones, bone pain, arthritis, deformities, also fractures.
Many people with Paget’s disease do not realize that they have it, as symptoms are often either mild or undetectable.
If a person with Paget’s disease fractures a bone, it may take a long time to heal because of faults in the bone renewal process.
